Neurofibroma solitario en maxilar superior: reporte de caso inusual / Solitary neurofibroma in upper maxillary: an unusual case report

Los neurofibromas solitarios han sido reportados en la literatura, pero son casos muy raros; por definición se presentan en pacientes que no tienen enfermedad de Von Recklinghausen, que se hereda en forma autosómica dominante, y se presenta con mayor frecuencia en hombres. Es un tumor benigno que puede presentarse solitario o múltiple; su aparición en la cavidad oral suele ser muy rara, pero su sitio de predilección es la lengua, seguido de la mucosa alveolar, paladar y encía gingival. Aparecen con más frecuencia durante la tercera década de vida, aunque se describen casos desde los 10 meses hasta los 70 años de edad. En este reporte se expondrá el caso clínico de un paciente de sexo femenino, de 17 años de edad, que acudió a consulta a la clínica dental centenario por presentar una lesión superior que cubría parte de las coronas anatómicas en piezas dentales del maxilar superior izquierdo, además, en el reporte de estudio inmunoquimicohistológico se diagnosticó neurofibroma, con expresión de S-100. Consideramos de suma importancia el reconocimiento de estos crecimientos intraorales para lograr establecer un diagnóstico definitivo cierto y veraz de la situación (AU)

Solitary neurofibromas have been reported in the literature, but they are very rare cases. By definition they occur in patients who do not have Von Recklinghausen disease, which is inherited in an autosomal dominant manner; It occurs more frequently in men. It is a benign tumor that can appear solitary or multiple. Its appearance in the oral cavity is usually very rare, but its site of preference is the tongue, followed by the alveolar mucosa, palate, and gingival gingiva. They appear more frequently during the third decade of life, although cases from 10 months to 70 years of age are described. This report will present the clinical case of a 17-year-old female patient who came to the Centennial Dental Clinic for consultation presenting an elevated lesion covering part of the anatomical crowns in dental pieces in the left upper jaw and in the report. Neurofibroma was diagnosed from the Immunochemicalhistological study, with S-100 expression. We consider the recognition of these intraoral growths of utmost importance in order to establish a true and truthful definitive diagnosis of the situation (AU)

Histological Evaluation of the Effect of Alendronate on the Maxillary Bone of Wistar Rats Combined with Orthodontic Movement of Intense Force / Evaluación Histológica del Efecto del Alendronate en el Hueso Maxilar de Ratas Wistar Combinado con Movimiento de Ortodoncia de Fuerzas Intensas

SUMMARY: To evaluate the histological adverse effects of alendronate administered systemically and topically in combination with orthodontic movement by intense force. Thirty-six 24-week-old female Wistar rats, ovariectomized, were used and divided into three groups (n = 12/group): control, locally treated with saline (0.07 ml/kg/week) (group 1) and experimental, treated with alendronic acid systemically (0.07 mg/kg/week) (group 2) and locally (7 mg/kg/week) (group 3). At 14 days, an orthodontic anchor was installed in the right first molar, and a force of 144 cN was applied for 28 days. The samples were processed for histological evaluation. Descriptive statistics, Shapiro-Wilk tests, one-way ANOVA with Bonferroni correction, one-way repeated measures ANOVA and chi-square tests were performed. All tests were statistically significant at p <0.05. The adverse events found in all groups were inflammation and osteoclastic activity. In the bisphosphonate-treated groups, there were statistically significant differences (p = 0.005) in the osteoclastic activity between the two hemiarcates. All rats in group 2 presented paralytic ileus. Compared to local administration, systemic treatment with alendronic acid produces more adverse effects, such as inflammation, fibrinoid necrosis, and osteoclastic activity. During the application of intense forces, it was not possible to show that there is necrosis associated with bisphosphonates.

Evaluar los efectos adversos histológicos del alendronato administrado sistémica y tópicamente en combinación con movimientos ortodóncicos de fuerza intensa. Treinta y seis ratas Wistar hembras de 24 semanas de edad, ovariectomizadas, fueron utilizadas y divididas en tres grupos (n = 12/grupo): control, tratado localmente con solución salina (0,07 ml/kg/semana) (grupo 1) y experimental, tratados con ácido alendrónico por vía sistémica (0,07 mg/kg/semana) (grupo 2) y local (7 mg/kg/semana) (grupo 3). A los 14 días se instaló un anclaje de ortodoncia en el primer molar derecho y se aplicó una fuerza de 144 cN durante 28 días. Las muestras fueron procesadas para evaluación histológica. Se realizó estadística descriptiva, pruebas de Shapiro-Wilk, ANOVA de una vía con corrección de Bonferroni, ANOVA de medidas repetidas de una vía y pruebas de chi-cuadrado. Todas las pruebas fueron estadísticamente significativas con un p <0,05. Los eventos adversos encontrados en todos los grupos fueron inflamación y actividad osteoclástica. En los grupos tratados con bisfosfonatos hubo diferencias estadísticamente significativas (p = 0,005) en la actividad osteoclástica entre los dos hemiarcados. Todas las ratas del grupo 2 presentaron íleo paralítico. En comparación con la administración local, el tratamiento sistémico con ácido alendrónico produce más efectos adversos, como inflamación, necrosis fibrinoide y actividad osteoclástica. Durante la aplicación de fuerzas intensas, no fue posible demostrar que existe necrosis asociada con los bisfosfonatos.

Conservative treatment of odontogenic fibromixoma in maxilla with 11-year follow-up: case report

Introduction: Odontogenic mixomas (OMs) are a locally infiltrating slow-growing intraosseous nonmetastasizing tumors of the maxilla and the mandible that have the potential for bone des-truction and cortical expansion, showing high recurrence rates. Their frequency varies around the world, accounting for 3-20% of all odontogenic tumors, ranking third among odontogenic tumors. They predominantly affect young adults, but may occur in various age groups. Report: A 37-year-old female patient who in August 2005 sought treatment at the Maxillofacial Dental Unit at Hospital Higueras, Talcahuano, Chile, for a left maxillary bone lesion. An increase in vo-lume was observed in the left maxillary region in the clinical analysis of the oral cavity. The neo-plasm was sessile and painless, measuring approximately 3 cm, with a greater diameter in the vestibule, firm on palpation and without signs of gangliopathy. Computed cone beam tomogra-phy imaging showed an extensive infiltrating osteolytic lesion in the left maxillary sinus, with noinvolvement of the orbital bone structure. Analysis of incisional biopsy yielded the diagnosis ofOdontogenic Fibromixoma. It was proposed to perform the conservative treatment of the lesion,consisting of enucleation and surgical curettage, obtaining excellent postoperative results and absence of relapse after 11-year follow-up. Conclusion: The present case report provides eviden-ce that supports the conservative surgical approach for the treatment of odontogenic myxomas, which contributes to a better postoperative quality of life for the patient.

Arch parameters and dental discrepancy (crowding and spacing) in a sample of an Afro-Colombian population / Parámetros de arco y discrepancia dental (apiñamiento y espaciamiento) en una muestra de población Afrocolombiana

The aim of this study was to determine the differences in arch length, inter-canine distance, inter-premolar distance, intermolar distance and arch shape between dental discrepancies (crowding and spacing) in a sample of dental casts from the Afro-Colombian population of San Basilio de Palenque. An analytical, cross-sectional study was conducted on a convenience sample of 63 subjects aged 11 to 57years, of Afro-Colombian origin, with full dentition from first molar to first molar, without extensive caries or restorations, and excluding casts with defects due to loss. The differences between arch (upper and lower) variables were analyzed according to dental discrepancies. Plaster models digitalized with a TR1OS3 Mono scanner with exactitude (6.9 ± 0.9 pm) and precision (4.5 ± 0.9 pm) were analyzed with Orthonalyzer software. Statistical analyses were done on SPSS software (Version 20 for Windows) and Real Statistics. Spacing discrepancy of68.25% was found for upper arch and 66.66% for lower arch; crowding discrepancy of 19.04% for upper arch and 20.63% for lower arch, and an adequate ratio of 12.69% for both arches. No statistically significant difference (p>0.05) was found between arch parameters except for inter-premolar distance on the lower arch. The most frequent arch shape in the population was oval for both upper arch, with 76.19%, and lower arch, with 71.42%. Tooth size was larger in males than females but the difference was not statistically significant.

El objetivo de este estudio fue determinar las diferencias en longitud de arco, distancia intercanina, interpremolar, intermolar y la forma de arco entre discrepancias dentales (apiñamiento y espaciamiento), en una muestra de modelos dentales de la población afrocolombiana de San Basilio de Palenque. Se realizó un estudio analítico transversal, en una muestra por conveniencia de 63 sujetos con un rango de edad entre 11 y 57 años, de origen afrocolombiano, quienes tuvieron dentición completa de primer molar a primer molar, sin caries extensas, ni restauraciones; se excluyeron los modelos con defectos por el vaciado. Se analizaron las diferencias entre las variables de los maxilares (superior e inferior) con las discrepancias dentales. Se utilizaron modelos de yeso que fueron digitalizados con el escánerTR1OS3 Mono con una exactitud de (6.9 ± 0.9 pm) y una precisión de (4.5 ± 0.9 pm)y analizados con el software Orthonalyzer. Los análisis estadísticos se llevaron a cabo utilizando el software SPSS (Versión 20 para Windows) y Real Statistics. Se encontró una discrepancia de espaciamiento de un 68,25% para el arco superior y 66,66% en el arco inferior; y una discrepancia de apiñamiento en el arco superior de 19,04% e inferior de 20,63% y una relación adecuada de 12,69% para los dos arcos. No se encontraron diferencias estadísticamente significativas (p>0.05) en los parámetros de arco a excepción de la distancia interpremolar del arco inferior. La forma de arco más frecuente en la población fue ovalada tanto en el arco superior con un 76,19% como en el arco inferior con un 71,42%. En cuanto al tamaño dental, se presentó mayor tamaño en los hombres que en las mujeres, pero este no fue estadísticamente significativo.

3D comparison of dental arch stability in patients with and without cleft lip and palate after orthodontic/rehabilitative treatment

Abstract This study aimed to compare the linear dimensions of the dental arches of adult patients with complete unilateral cleft lip and palate (UCLP) after orthodontic and prosthetic treatment with fixed partial dentures (FPD) to patients without clefts, using 3D technology. This retrospective longitudinal study sample consisted of 35 subjects divided into two groups. Included in this sample were 15 complete UCLP individuals who had received orthodontic treatment before rehabilitation with a fixed partial denture (FG), as well as 20 patients without cleft as control group (CG). All patients were aged between 18 and 30 years. Digital dental casts were obtained in two stages: (T1) end of orthodontic treatment and (T2) one year after prosthetic rehabilitation (FG); and (T1) end of orthodontic treatment and (T2) one year after removal of the orthodontic appliance (CG). Intercanine, interfirst premolar and intermolar distances, and incisor-molar length were obtained. A precalibrated and trained examiner performed the assessments. Intergroup differences between T2 and T1 were compared between the groups using the t test or Mann-Whitney test with a significance level of 5% (p<0.05). The intercanine distance variation (T2-T1) showed statistical difference (p=0.005) increasing in the FG group and decreasing in the CG group. In the interfirst premolar distance variation, FG decreased, while CG increased with statistically significant difference (p=0.008). The intercanine distance of individuals with cleft showed stability, while that of the CG had no stability. The CG showed stability in the interfirst premolar distance, while FG had no stability. These findings showed that the FPD is capable of restricting orthodontic results, leading to a stabilization of the dental arches.

The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ

Abstract Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient's symptoms under control. In this study, we aimed to investigate a new treatment protocol for medication-related osteonecrosis of the jaw (MRONJ). This treatment protocol consisted of administering human parathyroid hormone (hPTH) loaded chitosan microspheres which were prepared by ionotropic gelation method or/and the prepared microspheres were suspended in a poloxamer gel. After in-vitro optimization studies, the efficacy of the chosen formulations was evaluated in-vivo studies. Zoledronic acid was administered daily to forty-eight adult female Sprague-Dawley rats, divided into four experimental groups, at a daily concentration of 0.11 mg/kg over three weeks to induce the MRONJ model. At the end of this period, maxillary left molar teeth were extracted. In the first group, the subjects received no treatment. In the negative control group, poloxamer hydrogel containing empty microspheres were immediately applied to the soft tissues surrounding the extraction socket. The treatment group-1 was treated with local injections of poloxamer hydrogel containing hPTH. The treatment group-2 was treated with a single local injection of poloxamer hydrogel containing hPTH-loaded chitosan microspheres. Both treatment groups received a total of 7 µg of hPTH at the end of the treatment protocol. Our study demonstrates successful attenuation of MRONJ through a local drug delivery system combined with hPTH, as opposed to previously attempted treatment strategies.

Three-dimensional assessment of external apical root resorption after maxillary posterior teeth intrusion with miniscrews in anterior open bite patients

ABSTRACT Objective: The objective of this study was to assess the external apical root resorption (EARR) of the maxillary posterior teeth after intrusion with miniscrews. Methods: Fifteen patients (13 females and 2 males) with age ranging from 14.5 to 22 years (mean 18.1 ±2.03 years) were selected to participate in this study. All patients presented with anterior open bite of 3 mm or more. An intrusion force of 300 g was applied on each side to intrude the maxillary posterior teeth. Cone beam computed tomography (CBCT) scans were taken pretreatment and post-intrusion and were analyzed to evaluate the EARR. Results: The maxillary posterior teeth were intruded in average 2.79 ± 0.46 mm (p< 0.001) in 5.1 ± 1.3 months, and all examined roots showed statistically significant EARR (p< 0.05) with an average of 0.55 mm, except the distobuccal root of the left first permanent molars and both the palatal and buccal roots of left first premolars, which showed no statistically significant changes. Conclusions: The evaluated teeth presented statistically significant EARR, but clinically, due to the small magnitude, it was not considered significant. Moreover, the CBCT provided a good visualization of all roots in all three planes, and it was effective in detecting minimal degrees of EARR.

RESUMO Objetivo: o objetivo desse estudo foi verificar a existência de reabsorção radicular apical externa (RRAE) em dentes posterossuperiores após intrusão ancorada em mini-implantes. Métodos: quinze pacientes (13 mulheres e 2 homens) com a idade variando entre 14,5 e 22 anos (média de 18,1 ± 2,03 anos) foram selecionados para participar desse estudo. Todos os pacientes possuíam mordida aberta anterior de 3mm ou mais. Uma força de 300 gramas foi aplicada em cada lado para intruir os dentes posterossuperiores. Tomografias computadorizadas de feixe cônico (TCFC), adquiridas antes do tratamento e após a intrusão, foram comparadas para se avaliar a RRAE. Resultados: os dentes posterossuperiores foram intruídos em média 2,70 ± 0,46 mm (p< 0,001) em 5,1 ± 1,3 meses, e todas as raízes examinadas mostraram RRAE estatisticamente significativa (p< 0,05), com média de 0,55 mm, exceto pela raiz distovestibular dos primeiros molares permanentes esquerdos, e pelas raízes palatina e vestibular dos primeiros pré-molares esquerdos, que não apresentaram mudanças estatisticamente significativas. Conclusões: os dentes avaliados apresentaram RRAE estatisticamente significativa, a qual, porém, não foi considerada clinicamente significativa, devido à sua reduzida magnitude. Além disso, a TCFC possibilitou uma boa visualização de todas as raízes nos três planos espaciais, e foi eficaz para detecção de níveis mínimos de RRAE.

Clinical observation on soft and hard tissue changes of immediate implantation and immediate reconstruction in anterior region after loading 3 years / 北京大学学报(医学版)

OBJECTIVE@#To observe the change of soft and hard tissue in dental immediate implantation and immediate reconstruction in anterior region after loading 3 years.@*METHODS@#Patients with single anterior tooth loss in the Department of Second Dental Center, Peking University School and Hospital of Stomatology from October 2008 to October 2012 were enrolled. The gingival papilla height, labial gingival margin level and peri-implant bone level were measured immediately after the permanent restoration and 3 years later.@*RESULTS@#In the study, 20 patients were treated by immediate implantation and immediate reconstruction for 22 implants; 24 patients were treated by delayed implant for 29 implants. Implant stability quotient (ISQ) value of the two groups showed no significant difference before permanent restoration (P>0.05). In all the cases after loading 3 years, the average mesial gingival papilla height in implant area of the immediate group and delayed group changed by (0.34±0.54) mm and (0.05±0.39) mm respectively (P=0.07), the distal gingival papilla height changed by (0.43±0.42) mm and (0.36±0.48) mm respectively (P=0.13), while the labial gingival margin level shrinkages were (0.70±0.40) mm and (0.62±0.34) mm respectively (P=0.23). Peri-implant bone losses in the mesial side were (1.02±0.50) mm and (0.88±0.46) mm respectively (P=0.53), while those in the distal side were (1.05±0.34) mm and (0.95±0.47) mm respectively (P=0.21). All these indicators showed no significant difference between the two groups (P>0.05); When the permanent prostheses delivered, the distributions of the gingival papilla index were different between the two groups whether in the mesial side or in the distal side (P<0.05).@*CONCLUSION@#The changes of the soft and hard tissue of the immediate implantation and immediate reconstruction in anterior region after loading 3 years were basically equivalent to the conventional implant restoration. But, the former was obviously better than the latter in reducing the duration of treatment and in getting the ideal dental papilla aesthetic effect.

Oral implant osseointegration model in C57Bl/6 mice: microtomographic, histological, histomorphometric and molecular characterization

Abstract Despite the successful clinical application of titanium (Ti) as a biomaterial, the exact cellular and molecular mechanisms responsible for Ti osseointegration remains unclear, especially because of the limited methodological tools available in this field. Objective: In this study, we present a microscopic and molecular characterization of an oral implant osseointegration model using C57Bl/6 mice. Material and Methods: Forty-eight male wild-type mice received a Ti implant on the edentulous alveolar crest and the peri-implant sites were evaluated through microscopic (μCT, histological and birefringence) and molecular (RealTimePCRarray) analysis in different points in time after surgery (3, 7, 14 and 21 days). Results: The early stages of osseointegration were marked by an increased expression of growth factors and MSC markers. Subsequently, a provisional granulation tissue was formed, with high expression of VEGFb and earlier osteogenic markers (BMPs, ALP and Runx2). The immune/inflammatory phase was evidenced by an increased density of inflammatory cells, and high expression of cytokines (TNF, IL6, IL1) chemokines (CXCL3, CCL2, CCL5 and CXC3CL1) and chemokine receptors (CCR2 and CCR5). Also, iNOS expression remained low, while ARG1 was upregulated, indicating predominance of a M2-type response. At later points in time, the bone matrix density and volume were increased, in agreement with a high expression of Col1a1 and Col21a2. The remodelling process was marked by peaks of MMPs, RANKL and OPG expression at 14 days, and an increased density of osteoclasts. At 21 days, intimate Ti/bone contact was observed, with expression of final osteoblast differentiation markers (PHEX, SOST), as well as red spectrum collagen fibers. Conclusions: This study demonstrated a unique molecular view of oral osseointegration kinetics in C57Bl/6 mice, evidencing potential elements responsible for orchestrating cell migration, proliferation, ECM deposition and maturation, angiogenesis, bone formation and remodeling at the bone-implant interface in parallel with a novel microscopic analysis.

"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin

ABSTRACT The relationship between maxillary lateral incisor anodontia and the palatal displacement of unerupted maxillary canines cannot be considered as a multiple tooth abnormality with defined genetic etiology in order to be regarded as a "syndrome". Neither were the involved genes identified and located in the human genome, nor was it presumed on which chromosome the responsible gene would be located. The palatal maxillary canine displacement in cases of partial anodontia of the maxillary lateral incisor is potentially associated with environmental changes caused by its absence in its place of formation and eruption, which would characterize an epigenetic etiology. The lack of the maxillary lateral incisor in the canine region means removing one of the reference guides for the eruptive trajectory of the maxillary canine, which would therefore, not erupt and /or impact on the palate. Consequently, and in sequence, it would lead to malocclusion, maxillary atresia, transposition, prolonged retention of the deciduous canine and resorption in the neighboring teeth. Thus, we can say that we are dealing with a set of anomalies and multiple sequential changes known as sequential development anomalies or, simply, sequence. Once the epigenetics and sequential condition is accepted for this clinical picture, it could be called "Maxillary Lateral Incisor Partial Anodontia Sequence."

RESUMO A relação entre a anodontia parcial do incisivo lateral e o deslocamento palatino do canino superior não irrompido não pode ser considerada uma anomalia dentária múltipla com etiopatogenia genética definida, a ponto de ser considerada como uma "síndrome". Os genes envolvidos sequer foram identificados e localizados no genoma humano, e nem mesmo presumiu-se em qual cromossomo se localizaria o gene responsável. O deslocamento palatino do canino superior em casos de anodontia parcial do incisivo lateral superior está potencialmente associado às mudanças ambientais provocadas pela sua ausência no local de formação e erupção, o que caracterizaria uma etiologia epigenética para essa associação. A falta do incisivo lateral superior na região canina implica em tirar um dos guias referenciais da trajetória eruptiva do canino superior, que ficaria, assim, não irrompido e/ou impactado no palato. Como consequência, e em sequência, promove-se uma má oclusão, atresia maxilar, transposição, retenção prolongada do canino decíduo e reabsorções nos dentes vizinhos. Dessa forma, pode-se afirmar que estamos frente a um conjunto de anomalias e alterações múltiplas sequenciais conhecido como anomalias de desenvolvimento sequencial ou, simplesmente, sequência. Uma vez aceita a condição epigenética e sequencial para esse quadro clínico, ele poderia ser chamado de "Sequência da Anodontia Parcial do Incisivo Lateral Superior".

Agenesis of mandibular second premolar in patient with dental bimaxillary protrusion

ABSTRACT The present study reports the treatment carried out in a patient with mandibular second premolar agenesis associated with early loss of a deciduous second molar, deep overbite, severe overjet and dentoalveolar bimaxillary protrusion, which led to lip incompetence and a convex facial profile. The main objectives of this treatment were: to eliminate the spaces in mandibular arch, correct overbite, as well as eliminate bimaxillary protrusion and lip incompetence, thus leading to a balanced profile. The case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as part of the requirements to obtain the title of BBO diplomate.

RESUMO O presente caso clínico relata o tratamento de uma paciente com agenesia de segundo pré-molar inferior associada à perda precoce do segundo molar decíduo, sobremordida profunda, sobressaliência exagerada e biprotrusão dentoalveolar, que causavam incompetência labial e perfil facial convexo. Os objetivos do tratamento foram eliminar os espaços presentes na arcada inferior, corrigir a sobremordida, eliminar a biprotrusão e a incompetência labial, harmonizando o perfil. Esse caso foi apresentado ao Board Brasileiro de Ortodontia e Ortopedia Facial (BBO) como parte dos requisitos para obtenção do título de Diplomado pelo BBO.

Tratamiento de las discrepancias dentomaxilares en paciente clase II esqueletal. reporte de caso / Treatment of discrepancies dento-maxillary in patient class II skeletal. case report

La clase II esqueletal representa uno de los grandes desafíos a tratar por parte del Ortodoncista. Ésta se presenta cuando existe una discrepancia entre el maxilar y mandíbula, es decir puede haber un crecimiento excesivo del maxilar superior acompañado de una retrusión de la mandíbula. Esto provoca alteraciones tanto esqueléticas como dentarias, presentando apiñamientos, incompetencia labial o perfil convexo, pudiendo ser el tratamiento estrictamente ortodóntico o en ciertos casos requerir de cirugías máxilo faciales. El objetivo de esta investigación fue mejorar el perfil del paciente, conseguir Clase I molar y canina, corregir la incompetencia labial y mejorar la oclusión dental. El plan de tratamiento incluyó la extracción dental de primeros premolares superiores e inferiores y gracias a la aplicación de la técnica ROTH mediante el uso de cadenas elásticas y arcos de retracción se pudo cumplir el objetivo inicial, mejorando la estética y la función de las estructuras dento faciales.

Class II skeletal is one of the major challenges to be treated by the orthodontist. This occurs when there is a discrepancy between the maxilla and mandible, ie may have an overgrowth of the maxilla accompanied by a retrusion of the mandible. This causes both skeletal and dental alterations, presenting crowding, labial incompetence or convex profile and may be strictly orthodontic treatment or in certain cases require maxillo facial surgeries. The objective of this research was to improve the patient's profile, achieving Class I molar and canine, correct lip incompetence and improve occlusion. The treatment plan included tooth extraction first upper and lower premolars and thanks to the implementation of the ROTH technique using elastic chains and arches retraction could meet the initial objective,improving the aesthetics and function of the dento structures facial.

Rosai-Dorfman disease affecting the maxilla

Rosai-Dorfman disease (RDD), formerly called sinus histiocytosis with massive lymphadenopathy, is a non-neoplastic proliferative histiocytic disorder with behavior ranging from highly aggressive to spontaneous remission. Although the lymph nodes are more commonly involved, any organ can be affected. This study aimed to describe the features and the follow-up of a case of extranodal RDD. Our patient was a 39-year-old woman who was referred with an 11-month history of pain in the right maxilla. On clinical examination, some upper right teeth presented full mobility with normal appearance of the surrounding gingiva. Radiographic exams showed an extensive bone reabsorption and maxillary sinus filled with homogeneous tissue, which sometimes showed polypoid formation. An incisional biopsy demonstrated a diffuse inflammatory infiltrate rich in foamy histiocytes displaying lymphocytes emperipolesis. Immunohistochemistry showed positivity for CD68 and S-100, and negativity for CD3, CD20, and CD30. Such features were consistent with the RDD diagnosis. The patient was referred to a hematologist and corticotherapy was administrated for 6 months. RDD is an uncommon disease that rarely affects the maxilla. In the present case, the treatment was conservative, and the patient is currently asymptomatic after 5 years of follow-up.

Three-dimensional assessment of maxillary protraction with miniplates in patients with cleft lip and palate / Avaliação tridimensional da protração ortopédica da maxila com miniplacas em pacientes com fissura labiopalatina

The aim of this study was to assess maxillary, mandibular and glenoid fossa changes after bone anchored maxillary protraction (BAMP) therapy in patients with unilateral complete cleft lip and palate (UCLP). Methods: The experimental group comprised 24 patients with UCLP and maxillary sagittal deficiency with a mean initial age of 11.8 years. Cone-beam computed tomography (CBCT) exams of 24 patients with UCLP taken before (T1) and 18 months (T1) after beginning BAMP therapy were selected from the files of the Hospital of Rehabilitation of Craniofacial Anomalies. CBCTs were superimposed at the cranial base. Three-dimensional displacements of landmarks placed in surface models were quantified and visualized in color-coded maps and semi-transparency superimpositions. Kolmogorov-smirnov test was used to calculate distribution of normality. Paired t test was used to compare cleft and non-cleft sides (p<0.05). Results: A point and non-cleft central incisor displaced toward anterior (1.66mm), inferior (1.21mm) and to the cleft side. Orbitale, Infraorbitale foramen and maxillary first permanent molar displaced similarly toward anterior, inferior and medial direction. The zygoma displaced similarly toward anterior and inferior, however the cleft side showed a significantly greater lateral displacement compared to the non-cleft side. The superior concavity of the glenoid fossa showed symmetrical displacement toward anterior, lateral and superior, while the anterior and posterior eminences showed symmetrical displacements toward anterior, lateral and inferior. The mandible showed an overall symmetrical inferior and posterior displacement except for the medial pole of the condyle, which showed a significantly greater lateral displacement on the cleft side. Conclusions: Maxilla showed an anterior and inferior displacement. The glenoid fossa and the overall mandible symmetrically displaced downward and backward. The zygoma of the cleft side was the only maxillary landmark to show significantly greater lateral displacement than the non-cleft side, as well as the medial pole of the condyle on the cleft side.(AU)

O objetivo deste trabalho foi avaliar as alterações da maxila, mandíbula e fossa glenóide após o tratamento com protração maxilar ancorada em osso (BAMP) em pacientes com fissura unilateral completa de lábio e palato (UCLP). Métodos: o grupo experimental foi composto por 24 pacientes com UCLP e deficiência sagital de maxila com idade inicial de 11,8 anos. Foram selecionados exames de tomografia computadorizada de feixe cônico (CBCT) de 24 pacientes com fissura UCLP realizadas antes e após 18 meses de terapia com BAMP pertencentes ao Hospital de Reabilitação de Anomalias Craniofaciais. Os exames de CBCT foram sobrepostos pela base do crânio. Deslocamentos tridimensionais foram mensurados por meio de pontos colocados em modelos de superfície, bem como foram visualizados em mapas coloridos e sobreposições de semi-transparência. A distribuição de normalidade foi calculada por meio do teste de Kolmogorov-Smirnov. A comparação entre os lados com e sem fissura foi realizada por meio do teste t pareado (p<0.05). Resultados: O ponto A e o incisivo central superior do lado sem fissura deslocaram para anterior (1.66mm), inferior (1.21mm) e para o lado da fissura. Os pontos Orbitário, Forame Infra-orbitário e os primeiros molares permanentes superiores se deslocaram simetricamente para anterior, inferior e medial. O ponto Zigomático deslocou simetricamente para anterior e inferior, porém o lado da fissura apresentou um deslocamento significantemente maior para lateral comparado ao lado sem fissura. A concavidade superior da fossa glenóide apresentou um deslocamento simétrico para anterior, lateral e superior. As eminências anterior e posterior da fossa glenóide apresentaram um deslocamento simétrico para anterior, lateral e inferior. No geral, não houve diferença estatisticamente significante entre os lados com e sem fissura para o deslocamente inferior e posterior da mandíbula. O polo medial do côndilo foi o único ponto em que o lado da fissura apresentou um deslocamento significantemente maior para lateral quando comparado ao lado sem fissura. Conclusões: A maxila mostrou um deslocamento simétrico para anterior e inferior. A fossa glenóide e a mandíbula mostraram um deslocamento simétrico para inferior e para trás. Entretanto, os pontos zigomático e polo medial apresentaram um deslocamento lateral significantemente maior no lado da fissura.(AU)

Estudo comparativo das alterações cefalométricas do tratamento da má oclusão de Classe II com os aparelhos propulsores jasper jumper e forsus fatigue resistant device, associados ao aparelho fixo / Treatment effects produced by the jasper jumper vs the forsus fatigue resistant device, associated with fixed orthodontic appliances, in growing Class II patients

Objetivo: O objetivo deste estudo foi comparar as alterações cefalométricas depacientes com má oclusão de Classe II divisão 1 tratados com os aparelhos JasperJumper e Forsus Fatigue Resistant Device, associados ao aparelho ortodôntico fixo.Material e métodos: A amostra foi constituída por 124 telerradiografias em normalateral de 62 indivíduos, os quais foram divididos em 3 grupos: Grupo Experimental 1(n=22, idade inicial=12,39 anos), tratados por meio do aparelho Jasper Jumperassociado ao aparelho fixo, por um período médio de 2,43 anos; Grupo Experimental2 (n=19, idade inicial=12,43 anos), tratados com o aparelho Forsus associado aoaparelho fixo, com tempo médio de tratamento de 3,54 anos; Grupo Controle (n=22,idade inicial 12,14 anos), observados por um período médio de 1,78 anos. Asalterações de todas as variáveis cefalométricas dos grupos experimentais foramanualizadas e, posteriormente, comparadas às alterações das variáveis do grupoControle, por meio da Análise de Variância e do teste de Tukey. Resultados:Observou-se que ambos os tratamentos apresentaram um efeito restritivo na maxila;não alteraram o desenvolvimento mandibular; melhoraram a relaçãomaxilomandibular; promoveram rotação horária do plano oclusal e um suaveaumento da altura facial anteroinferior. Os grupos experimentais apresentaramlimitação do desenvolvimento vertical dos molares superiores; inclinação paravestibular e limitação do desenvolvimento vertical dos incisivos inferiores; e extrusãodos molares inferiores. Os incisivos inferiores exibiram maior protrusão no grupo 1em relação aos demais grupos. Ambos os aparelhos melhoraram significantementea relação maxilomandibular, os trespasses horizontal, vertical e a relação molar. Osprotocolos de tratamento promoveram retrusão dos lábios superiores. O grupo 2apresentou suave protrusão dos lábios inferiores e os grupos 1 e 3 apresentarampequena retrusão...

Objective: The aim of this study was to compare the cephalometric changes of ClassII division 1 malocclusion patients treated with Jasper Jumper and Forsus FatigueResistant Device, associated with fixed appliances. Methods: The sample consistedof 124 lateral cephalograms of 62 individuals, divided into 3 groups: Group 1 (n=22,mean age=12.39 years), treated with the Jasper Jumper appliance associated withfixed appliances for a mean period of 2.43 years; Group 2 (n=19, mean age=12.43years), treated with the Forsus appliance associated with fixed appliances, with amean treatment time of 3.54 years; and the Control group (n=22, mean age=12.14years), followed for a mean period of 1.78 years. The changes of all cephalometricvariables in the study groups were annualized and then compared to the changesobserved for the Control group, by analysis of variance and Tukey test. Results: Itwas observed that both treatments presented a restrictive effect on the maxila; didnot change the mandibular development; improved maxillomandibular relationship;produced clockwise rotation of the occlusal plane; and a slight increase in loweranterior facial height. Study groups showed limitation on the vertical development ofthe maxillary molars; buccal tipping and limitation on the vertical development of themandibular incisors; and extrusion of mandibular molars. The mandibular incisorsexhibited greater protrusion in the group 1 compared to other groups. Bothappliances provided significant improvement of maxillomandibular relationship,overjet, overbite and molar relationship. Treatment protocols promoted retrusion ofthe upper lip. Group 2 presented mild protrusion of the lower lip and groups 1 and 3showed mild retrusion. Conclusion: Both the appliances were effective in thetreatment of Class II malocclusion.

Estudo comparativo das alterações cefalométricas do tratamento da má oclusão de Classe II com os aparelhos propulsores jasper jumper e forsus fatigue resistant device, associados ao aparelho fixo / Treatment effects produced by the jasper jumper vs the forsus fatigue resistant device, associated with fixed orthodontic appliances, in growing Class II patients

Objetivo: O objetivo deste estudo foi comparar as alterações cefalométricas depacientes com má oclusão de Classe II divisão 1 tratados com os aparelhos JasperJumper e Forsus Fatigue Resistant Device, associados ao aparelho ortodôntico fixo.Material e métodos: A amostra foi constituída por 124 telerradiografias em normalateral de 62 indivíduos, os quais foram divididos em 3 grupos: Grupo Experimental 1(n=22, idade inicial=12,39 anos), tratados por meio do aparelho Jasper Jumperassociado ao aparelho fixo, por um período médio de 2,43 anos; Grupo Experimental2 (n=19, idade inicial=12,43 anos), tratados com o aparelho Forsus associado aoaparelho fixo, com tempo médio de tratamento de 3,54 anos; Grupo Controle (n=22,idade inicial 12,14 anos), observados por um período médio de 1,78 anos. Asalterações de todas as variáveis cefalométricas dos grupos experimentais foramanualizadas e, posteriormente, comparadas às alterações das variáveis do grupoControle, por meio da Análise de Variância e do teste de Tukey. Resultados:Observou-se que ambos os tratamentos apresentaram um efeito restritivo na maxila;não alteraram o desenvolvimento mandibular; melhoraram a relaçãomaxilomandibular; promoveram rotação horária do plano oclusal e um suaveaumento da altura facial anteroinferior. Os grupos experimentais apresentaramlimitação do desenvolvimento vertical dos molares superiores; inclinação paravestibular e limitação do desenvolvimento vertical dos incisivos inferiores; e extrusãodos molares inferiores. Os incisivos inferiores exibiram maior protrusão no grupo 1em relação aos demais grupos. Ambos os aparelhos melhoraram significantementea relação maxilomandibular, os trespasses horizontal, vertical e a relação molar. Osprotocolos de tratamento promoveram retrusão dos lábios superiores. O grupo 2apresentou suave protrusão dos lábios inferiores e os grupos 1 e 3 apresentarampequena retrusão...

Objective: The aim of this study was to compare the cephalometric changes of ClassII division 1 malocclusion patients treated with Jasper Jumper and Forsus FatigueResistant Device, associated with fixed appliances. Methods: The sample consistedof 124 lateral cephalograms of 62 individuals, divided into 3 groups: Group 1 (n=22,mean age=12.39 years), treated with the Jasper Jumper appliance associated withfixed appliances for a mean period of 2.43 years; Group 2 (n=19, mean age=12.43years), treated with the Forsus appliance associated with fixed appliances, with amean treatment time of 3.54 years; and the Control group (n=22, mean age=12.14years), followed for a mean period of 1.78 years. The changes of all cephalometricvariables in the study groups were annualized and then compared to the changesobserved for the Control group, by analysis of variance and Tukey test. Results: Itwas observed that both treatments presented a restrictive effect on the maxila; didnot change the mandibular development; improved maxillomandibular relationship;produced clockwise rotation of the occlusal plane; and a slight increase in loweranterior facial height. Study groups showed limitation on the vertical development ofthe maxillary molars; buccal tipping and limitation on the vertical development of themandibular incisors; and extrusion of mandibular molars. The mandibular incisorsexhibited greater protrusion in the group 1 compared to other groups. Bothappliances provided significant improvement of maxillomandibular relationship,overjet, overbite and molar relationship. Treatment protocols promoted retrusion ofthe upper lip. Group 2 presented mild protrusion of the lower lip and groups 1 and 3showed mild retrusion. Conclusion: Both the appliances were effective in thetreatment of Class II malocclusion.

Osteonecrose dos maxilares associada ao uso dos bisfosfonatos / Bisphosphonates-related osteonecrosis of the jaws

A osteonecrose dos maxilares associada ao uso de bisfosfonatos tem sido um assunto de muita relevância na clínica odontológica neste século. A alta taxa de utilização desses medicamentos obrigou os cirurgiões-dentistas a buscar conhecimento sobre o tema, uma vez que as lesões necróticas associadas ao uso desses bisfosfonatos afetam negativamente a qualidade de vida e produzem significativa morbidade nos pacientes acometidos. Assim, conhecer a doença, sua epidemiologia, taxa de risco e gerenciamento dos pacientes se faz necessário. Objetivo: o presente trabalho teve como objetivo geral buscar na literatura informações relevantes acerca dessa patologia e desses medicamentos, por meio de uma revisão de literatura. Métodos: levantamento de artigos nas bases de dados EBSCO e MEDLINE, publicados no período de 1996 a 2014. Foram selecionados artigos originais e de revisão que embasaram o desenvolvimento dos tópicos propostos. Resultados: 22 artigos preencheram os critérios estabelecidos. Durante o desenvolvimento da pesquisa, foram encontrados outros medicamentos associados à enfermidade, que também estão sendo relatados nessa revisão. Conclusões: devido à utilização dos bisfosfonatos, o tecido ósseo diminui sua capacidade de reabsorção e, assim, aumenta a possibilidade de não cicatrização e consequente necrose; ainda, fica clara a ação desses medicamentos inibindo a proliferação de células dos tecidos moles e vasos sanguíneos. Por último, evidencia-se que o correto gerenciamento dos pacientes em uso dos fármacos é de grande importância para a submissão desses pacientes a procedimentos cirúrgicos...

Osteonecrosis of the jaw associated with the use of bisphosphonates has been a relevant subject in Dentistry in the last century. The excessive use of these medications obligated dentists to seek knowledge on the theme, since necrotic lesions associated with the use of bisphosphonates affect quality of life negatively, in addition to causing significant morbidity. Thus, being aware of the disease, its epidemiology, risk rate and patient management is necessary. The present study aimed to search literature on relevant information regarding the referred pathology and medications by means of a review. Methods: EBSCO and MEDLINE databases were used, seeking articles published between 1996 and 2014. Original and review articles were selected to base the development of proposed topics. Results: A total of 22 articles fulfilled the established criteria. During the development of the study, other medications associated with the pathology were found and are also reported in this review. Conclusions: Due to the use of bisphosphonates, bone tissue diminishes its resorption capacity and, thus, increases the probability of non-healing and consequent necrosis. In additionthe effects of these medications, inhibiting soft tissue cells and blood vessels proliferation, are clear. At last, it is clear that the correct management of patients using such drugs is of great importance to their submission to surgical procedures...

Adenomatoid Odontogenic Tumor: A Case Report.

Adenomatoid odontogenic tumor (AOT) is a very rare odontogenic tumor with an incidence of 1%. Overall it accounts for 9% of all odontogenic tumors. In most of the cases, AOT is misdiagnosed as an odontogenic cyst. Younger individuals are commonly affected and particularly in females. AOT is seen predominantly in the maxillary anterior region in association with an unerupted tooth. Permanent dentition is affected more than the deciduous dentition. Intraoral periapical radiographs play a major role in the diagnosis compared to orthopantomogram because of its increased contrast but for the better assessment of the extension of larger lesions orthopantomogram is must. AOT resembles benign odontogenic lesions like dentigerous cyst and tumors like ameloblastoma. The lesions are managed conservatively by surgical excision along with the removal of the affected tooth and have an excellent prognosis.With this background, we report an unusual case of AOT involving maxillary anterior region in 15-year-old male patient. The present article reviews the etiology, clinical features, histopathological features, and treatment modalities of AOT.

Central Ossifying Fibroma of the Maxilla (Matured Type): Report of a Rare Case.

Central ossifying fi broma is a bony tumor, which is believed to be derived from the cells of the periodontal ligament. Central ossifying fi broma behaves like, a benign bone neoplasm. Th is bone tumor consists of highly cellular, fi brous tissue that contains varying amounts of calcifi ed tissue resembling bone, cementum, or both. Central ossifying fi bromas of the mandible are common; however, they are rare in the maxillary region however they are common in the mandible, have got a female predeliction and is usually seen in the age between 35 and 40 years of age. In this report, we have described a 35-year-old female with minimal clinical symptoms diagnosed as central ossifying fi broma in the anterior maxillary region.

Odontogenic Myxoma Involving the Maxilla: Case Report of a Rare Entity.

Odontogenic myxomas (OMs) are rare, benign, slow-growing tumors that may arise in the maxilla. They are known to have a female predilection and present as a painless mass commonly in the second or third decade of life, comprising 3-6% of all odontogenic tumors. They show a locally aggressive behavior, are radioresistant tumor and hence the need for early recognition and surgical resection. A high rate of recurrence has also been noted owing to its infiltrative pattern of growth and lack of capsule. Clinical and radiological aspects of maxillary OMs are not conclusive hence it is necessary to have a histopathological exam for the final diagnosis. We present a case of OM involving the maxilla in a 51-year-old female patient. The various histopathological differentials are also discussed.